José Luis Talamillo Huidobro (6 July 1933 – 31 December 1965) was a Spanish cyclist, who competed as a professional from 1957 until 1965.
As a road cyclist he won, among other things, the GP Villafranca de Ordizia in 1959 and the Setmana Catalana de Ciclisme in 1965.
During the 1961 Vuelta a España, Talamillo held the leader's jersey for two days.
He also rode in the 1964 Giro d'Italia, finishing 59th overall.
Talamillo was killed in a traffic accident on the road between Burgos and Logroño on December 31, 1965, leaving behind a wife and two children.