He took music classes from Friar Juan Altamiran, of the convent "Nuestra Señora de las Mercedes", and learned to draw from Mr. Rafael U. Martínez, a Guatemalan painter located in Honduras.

On June 20,1815, in order to continue his studies, Reyes left Tegucigalpa for León, Nicaragua under the guard of a farmworker named Miguel Alvarez.

In 1825, he began his religious profession as deacon and priest, receiving orders from the bishop of the city, Garcia Jeredue.Due to the civilwar in Nicaragua during 1825, the Recoletos were expelled and saw themselves forced to go to Guatemala.

In 1830, Trinidad Reyes wrote in verse a birthday felicitation to General Francisco Morazán, president of the Federal Republic of Central America.

He also helped to Mr. Antonio Tranquilino de la Rosa in the reparation of the Parochial Church of Tegucigalpa, which was in ruins due to land tremors at 1809.

In February 1837, Reyes pronounced a praise sermon to mark the restoration of Parochial Church of Tegucigalpa, where he opened his Mass called "El Tancredo".

The same year, he contracted Asian cholera during his work helping victims, and barely survived after being "between life and death", according to Ramón Rosa.

On December 14 of that year, he installed himself at the Government House, the "Society of the Enterprising Genius and Good Taste", where he later founded the Honduras Autonomous University.

On September 19, Trinidad Reyes opened the Honduras' University, chairing the event with the chief of state Mr Juan Lindo and Bishop Campoy y Perez.

On February 9, 1848, Reyes wrote his well-known "Invitation to stroll to the lake" to the society of Tegucigalpa, made by petition of students.

In 1849, his father died, due to mental illness.On April 16 of 1850, Reyes wrote his poem Honduras, which has six octaves in ten syllables and is dedicated to the generals Gerardo Barrios and Trinidad Cabañas, and all soldiers, officers and chiefs of El Salvador and Honduras.On September 29 of the same year, he wrote his poem "To the independence", which consists of seven octaves in ten syllables, and a quartet as the epigraph.

This year he published his Elementary Lessons of Physics, which in March, with the Printer of Academy, became a study book for the youth of the time.

Before June, he traveled to the city Comayagua, to visit the bishop, Hipólito Casiano Flores, who had come to consecrate himself from El Salvador, and who he accompanied on his first Pontifical Mass, according to Ramón Rosa.

In his final year, he wrote his most poetically successful pastorela, Olympia, named probably by inspiration of the French feminist Olympe de Gouges, murdered by her struggle for equality between men and women.

This work was dedicated to a young lady, Trinidad Boquín.He retired to the country, to the neighboring village of Soroguara, to recover his health, and returned in late August to Tegucigalpa, where, he was on his deathbed until his death on September 20 at 10am, surrounded by his disciples and families in the room now occupied by the National Archive.