Vizcaíno made his debut with the Dodgers as a late-season call-up in 1989, where he played five games at shortstop for them to conclude the season.

The Cubs traded Vizcaíno to the New York Mets on March 30, 1994, for Anthony Young and minor-leaguer Ottis Smith.

When play resumed in 1995, Vizcaíno responded with his best season to that point, collecting 146 hits, including a career-high 21 doubles and 56 runs batted in, although his strikeouts increased slightly to 76.

On July 29, 1996, Vizcaíno was traded to the Cleveland Indians along with Jeff Kent for Carlos Baerga and Alvaro Espinoza.

In the 1996 American League Division Series against the Baltimore Orioles, Vizcaíno collected four hits (including two doubles) and one run batted in.

On November 13, 1996, he was traded to the San Francisco Giants along with Matt Williams and a player to be named later (Joe Roa) and Trent Hubbard along with Jeff Kent and Julián Tavárez.

In the postseason, Vizcaíno collected two hits and one run while striking out five times as the Giants were defeated by the Florida Marlins.

In the bottom of the 12th inning of the then longest game in World Series history, Vizcaíno hit the game-winning RBI single.

Instead, he signed a one-year contract with the San Francisco Giants, who designated pitcher Brian Burres for assignment to make room for him on the roster.

On August 23, 2006, Vizcaíno was signed to a contract by the Cardinals and spent the rest of the 2006 season as a replacement for injured shortstop David Eckstein.

Vizcaíno was hired as a Special Assistant of Baseball Operations in the Los Angeles Dodgers front office in January 2008.