Van Immerseel studied organ, piano and harpsichord at the Antwerp Conservatory under Flor Peeters, Eugène Traey and harpsichordist and musicologist Kenneth Gilbert.

He created the Collegium Musicum there, developing his interest in Renaissance and Baroque music, later expanding his activities to include the Classical and early Romantic eras.

[1] This ensemble has become well-known and achieved a world-wide reputation particularly for the CD series of Mozart's complete piano concerti (with van Immerseel as soloist and conductor).

He has also taught at the Sweelinck Conservatorium in Amsterdam and the Conservatoire National Supérieur in Paris, as well as given masterclasses at festivals in La Roque-d'Anthéron, Utrecht, Sopron and Ancona.

Accomplished on the organ and piano as well as harpsichord and fortepiano, Van Immerseel has in particular gained a reputation for his performances of Mozart, Beethoven and Schubert on Sony Classical.