She is survived by their children Myki, a medical doctor, Benj Manalo married to Lovely Abella, Sherwin Nicco, an actor, Ai, an accounts manager, and Colyn, a musician.

Manalo also appeared in several sitcoms on GMA Network like Daddy Di Do Du and Ful Haus, both starring Vic Sotto.

[7] Together, collectively known as the "Legit Dabarkads", moved to TV5 to host a new program entitled E.A.T., later renamed as Eat Bulaga!

[10][12] In late 2013, however, Manalo's daughter filed a case of violation against her father for failure to provide financial support, which caused her to drop out of school.

[13] The following year, his daughter subsequently attempted suicide, citing her family problems and mainly blaming her father as the reason.

[15] In 2022, the Court of Appeals absolved Manalo from civil liability arising from his wife Annalyn's P 50 million debt to businessman Froilan Clemente Jr.