He is best known for portraying Lola Nidora and other characters in the Kalyeserye portion of the noontime television variety show Eat Bulaga!.

Bayola was raised by Francisco Nepomuceno, a priest and his maternal great-uncle, at a convent of a Catholic church in Naga, Camarines Sur.

On March 2, 2012, Bayola and Manalo had their first concert, Jose and Wally Show: A Party for Juan and All, at the Smart Araneta Coliseum.

On September 2, 2013, a video showing Bayola and "EB Babe" Yosh Rivera engaging in sexual intercourse, was uploaded to YouTube.

On August 10, 2023, Bayola and co-host, Jose Manalo were doing a skit on the show's Sugod Bahay, Mga Kapatid!

Meanwhile, Bayola disappeared from the screen but accidentally uttered the Tagalog expletive "putang ina" off-screen that caught everyone's attention.

[12][13] A day later, on August 11, 2023, Bayola expressed regret and sincerely apologized for the incident and admitted that he had made a mistake.

[14] After Bayola's heartfelt apology to viewers and fans, the Movie and Television Review and Classification Board (MTRCB) issued a “Notice to Appear and Testify” to the production group of the TV5's noontime show, E.A.T., regarding a hearing over the utterance of profanity by one of its hosts, Wally Bayola.