[1][2] Desch was born in Dayton, Ohio, in 1907 into a family of German descent whose livelihood was blacksmithing and wagon-making.
Two years later he was hired by Harry Williams to be foreman on the Process Laboratory at the Frigidaire Division of General Motors, once again in Dayton.
He then followed Williams to the National Cash Register Company in 1938 to form the innovative Electrical Research Laboratory at the direction of Edward A.
As a result Desch's lab received an introduction to and work with the MIT Electrical Engineering Department led by Vannevar Bush.
Believing that the American version of the bombe decryption machine could be built using mechanical and electronic components, and recognizing the National Cash Register Company's capabilities, the Navy moved ahead with a contract.
The pressure of cryptanalytic work and the continuing toll of the loss of life in the Pacific theater led to Desch's withdrawal from the project in late 1944.
His career after this point was noteworthy, and he was especially proud in later years of his work with Bob Mumma in the development of the NCR 304, the first completely solid state computer.