Born in to a family of a non-commissioned officer of working-class origin in Brussels, in 1899 he graduated from the cadet school and served in the army for some time.

He led the revolutionary syndicalist opposition in the reformist trade unions, seeking to rebuild it along the lines of the General Confederation of Labor in France.

In September, together with War van Overstraten and other revolutionary leaders, he formed the basis for the creation of the Communist Party of Belgium (CPB), in which Jacquemotte was elected a member of the Central Committee.

Jacquemotte, in his post, defended the unity of action between the communists and the socialists and other progressive forces, even to the point that he raised the issue of the collective entry of the CPB into the Belgian Labor Party in order to create a "formidable and cohesive bloc of the main currents of the working class".

He died suddenly in October 1936, while on a train taking him back to Brussels from the printers of La Voix du Peuple, the party's daily newspaper that became the successor to L'Exploité.