Joseph S. Manasse (August 3, 1831 – December 26, 1897) was an early settler of San Diego, California.

Manasse was born in 1831 in Filehne, Prussia and came to San Diego in 1853 with his brother Heyman and cousin Moses.

In 1856, he formed a long-time partnership with Marcus Schiller, who was called a "Jewish Horatio Alger" by a biographer.

They bought a lumberyard at the foot of E Street in 1868, and were the first to bring lumber ships into San Diego Bay.

They built up a large business, but suffered severely in the drought, hard times, the early 1870s, and the great fire at Old Town in April 1872.