[4] Little was 16 years old at the time of his debut, making him the second-youngest to have played at that level,[5] after Hong Kong's Waqas Khan.
[19] On 4 November 2022, in a match against New Zealand in the 2022 T20 Cricket World Cup, Little took a hat-trick by dismissing Kane Williamson, James Neesham and Mitchell Santner.
[21][22][23] He also became the second Irish bowler to take a hat-trick in a T20I match after Curtis Campher and both in fact achieved the milestones in T20 World Cup tournaments.
[26] He excelled at the 2016 U-19 World Cup having picked up a haul of 11 wickets which also helped him to be fast-tracked into the senior Irish side within a year.
It was Graham Ford who shaped the mentality of Little to make him seriously consider about making cricket as a professional career and in an exclusive interview with Sunday Times Ireland, Little described that "five-minute chat with Ford changed his entire perception of things and since then he has been head down, just gym and cricket".
[30] In July 2019, Little was selected to play for the Dublin Chiefs in the inaugural edition of the Euro T20 Slam cricket tournament.
[33] In November 2021, he was selected to play for the Dambulla Giants following the players' draft for the 2021 Lanka Premier League.
[34] He was roped in by the Chennai Super Kings franchise as its net bowler ahead of the 2022 Indian Premier League.
[36] He was eventually Manchester Original's second highest-wicket taker during the course of the 2022 Hundred season with a wicket tally of 13 in just five innings and was only behind Paul Walter's 14 scalps.
He is the fourth person to obtain a 5 wicket haul in the history of the competition sending Manchester Originals into the top three on the final day and into the playoffs.