Since 2007, Reiss has led a team at the Queen Mary University of London, Centre for Digital Music, that pioneers research into intelligent audio production technologies.

Scientific breakthroughs from Reiss' team include the development of automated multitrack signal processing, concerned with how best to mix a collection of individual sources to achieve a combined signal with preferred characteristics, together with advances in psychoacoustics, and an emphasis on understanding human perception of complex sound mixtures.

[4] Past members of his research team include Enrique Perez Gonzalez, CTO of SSL, and Stuart Mansbridge, chief music technology officer at LANDR.

[8][9] Based on the breakthroughs of his research team in intelligent music production systems, Reiss co-founded the company MixGenius in 2012.

[15] Reiss has gained worldwide news coverage for his research on acoustic feedback prevention and automatic mixing and has appeared in features in New Scientist, The Engineer, The Guardian, AV Magazine, Audio!, ProSoundNews, La Presse, BBC Radio 4, BBC World Service, Channel Four, Radio Deutsche Welle, LBC and ITN, Telegraph podcast and AES podcast.