It was established in 1967 by David E. Smith and is currently published five times per year by Taylor & Francis.

It was previously titled Journal of Psychedelic Drugs until 1980.

[1][2] It was the first journal established in the United States to focus on psychoactive drug use, and continues to introduce groundbreaking work in topics such as drug use and criminality, therapeutic communities, dual diagnosis, psychotherapy/counseling, methadone maintenance treatment, and culturally-relevant substance abuse treatment.

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