Joy is also known for her recurring role on Grey's Anatomy, her voicing of the Failsafe AI in the video game Destiny 2 and Jing Harris in Duncanville.
She has also appeared on the TV shows Good Job, Thanks!, Men of a Certain Age (as Lindsey), Dwelling (as Thai Lady), Chaos (as Unchin Song) and Numb3rs.
She has also starred in the TV movies Family Album (as Holly Shapiro), Nathan vs. Nurture (as Lexi Miller), Five Year Plan (as Judy).
Joy Osmanski has also provided the voice of the Failsafe AI, a non-playable character in Bungie's video game Destiny 2 alongside Nolan North, Lance Reddick, Nathan Fillion, and more.
In 2020, Osmanski was cast in a recurring role on DC Universe/The CW’s Stargirl as supervillain Paula Brooks / Tigress for the shows first two seasons.