Juan Manuel Rodríguez (31 December 1771 – 1847) was a Salvadoran revolutionary against Spain and later president of the State of El Salvador within the Federal Republic of Central America (briefly in 1824).

He was commissioned along with Arce and other deputies of the provincial congress to negotiate in Washington, D.C. for the admission of El Salvador to the United States.

The government also decreed the foundation of the Diocese of San Salvador and made Father José Matías Delgado, a hero of the independence movement, the first bishop.

During Rodríguez's term of office, the first official printing press in El Salvador entered service (June 1824).

After supporting the party of the fiebres for years and serving as treasury secretary, Rodríguez retired to private life.