She was the wife of the 39th vice president of the United States, Spiro Agnew, who had previously served as Governor of Maryland and Baltimore County Executive.

Although Judy Agnew attempted to avoid political discussion during her tenure as second lady, preferring to cultivate her image primarily as a wife and mother, her dismissive remarks about the women's liberation movement were quoted by media.

[3] After meeting again at the Maryland Casualty Company, the couple went to a movie on their first date together, and bought chocolate milkshakes afterward.

[4] While living in Annapolis with her husband and their four children, Agnew served as the president of her local PTA, and volunteered as both an assistant Girl Scout troop leader[1] and a board member of the Kiwanis Club women's auxiliary.

[1] She became known by the local press for serving cocktails in glass peanut butter jars,[5] although she once publicly attempted to refute this claim.

[2] McCall's magazine published a letter from a feminist reader in response to Agnew's comments, saying she had "set Women's Lib back a hundred years".

[1] In 1973, Spiro Agnew resigned from his position as Vice President of the United States, pleading nolo contendere to charges of income tax evasion.