[2] Huxtable's multidisciplinary art practice explores a number of projects, such as the internet, the body, history, and text, often through a process she calls "conditioning.

While at the ACLU, Huxtable amassed a significant following on Tumblr, posting long stream-of-consciousness poems and self-portraits that experimented with fashion and Nuwaubian imagery.

Huxtable's poetry was featured in the song "Blood Oranges" from Le1f's mixtape Tree House as well as the runway soundtrack for the Hood by Air 2014 Fall/Winter fashion show "10,000 Screaming Faggots" by Total Freedom.

In 2014, she was featured on the fifth anniversary cover of C☆NDY magazine along with a number of other transgender women – Janet Mock, Carmen Carrera, Geena Rocero, Isis King, Leyna Ramous, Yasmine Petty, and Laverne Cox.

The band's primary member, Andrew Butler, described the song and its video as an examination of his "relationship to taboo words and the use of 'cunt' amongst NYC's gay community to relay flattery, empowerment and strength".

[17] In early 2015, Huxtable was selected to present work in the 2015 New Museum Triennial Surround Audience, curated by Lauren Cornell and artist Ryan Trecartin.

[8] She premiered on season two of Ovation TV's web-based talk show, Touching the Art, hosted by fellow 2015 Triennial artist Casey Jane Ellison.

[20] It included poetry, audio and voice over, video elements, and live-music with fellow collaborators and explored the complicated relationship between the ephemeral nature of digital information and the drive for historical documentation on the internet.

As described by the festival's organizers, Huxtable's performance considered "cyberspace as a twilight zone of precariousness and preservation, traversing closed servers, bounced URLs, and Google cache as human and digital characters".

[21] Huxtable is a founder and DJ for Shock Value, a weekly New York City–based nightlife collective run by women artists, DJs, writers, and fashion icons.

[25] Huxtable currently sits on the editorial board for Topical Cream, a New York–based platform that supports a community of artists, writers, designers, and technologists through digital publishing and public programming initiatives.

The duo produced two tracks on Locus Error, an acid techno concept album released through Nina Kraviz's Trip Records.

Huxtable's more recent works explore language, conspiracy theories, fashion (Baroque costumes, military surplus, punk aesthetics, etc.

"[42] Huxtable often, "references her use of digital spaces, including Tumblr," chat rooms, social media, online sexual subcultures, Encarta, and Afripedia as well as childhood, fashion, consumer culture, and the African diaspora.

[43] Huxtable has noted a range of influences including writers Octavia Butler and Samuel R. Delany, theorists Luce Irigaray and Jose Esteban-Muñoz, and the visual aesthetics of video director Hype Williams, bands TLC and Blaque, and singer Aaliyah.