She began tap, ballet and jazz dancing at an early age, and continued singing in the choir while enrolled at R.J. Reynolds High School,[5] where she graduated in 2005.
She performed in local theater productions and attended New York University before moving to Los Angeles.
[12] The following week saw the release of the horror film Altitude, with Guill starring opposite Jessica Lowndes.
[13][14] In 2010, Guill was cast in the lead role of Christie DeWitt on the TBS comedy drama series Glory Daze.
[21] From 2014 to 2017, she played the recurring role of Becca Riley on the Bravo comedy drama series Girlfriends' Guide to Divorce.