Andem is most famous for being the creator, screenwriter, director, and showrunner for the internationally acclaimed Norwegian young adult internet/television series Skam, which aired from 2015 to 2017 on Norway's public broadcasting network, NRK.

At NRK, she created and wrote the show Jenter, which means "girls" in Norwegian.

[3][4] Skam began because NRK executives wanted to reach more teenage girls in its programming.

Andem, along with Mari Magnus who later became the social media director of the series, spent six months traveling around Norway and interviewing teenagers about their lives.

[6] In October 2019, it was announced that Andem signed a two-year contract with HBO to create and develop shows for the network.