A self-taught programmer, Larson-Green completed her master's degree in software engineering and was then recruited as development lead at Aldus.

In November 2012, Larson-Green was promoted to be the head of all Windows software and hardware engineering, in the wake of the sudden departure of Steven Sinofsky.

[11] Larson-Green was the 2015 winner of the Woman of Vision ABIE Award for Leadership from the Anita Borg Institute.

[12][13] As part of a Microsoft reorganization in July 2013, Larson-Green was named as the head of the newly formed Devices and Studios Engineering Group.

[19] In November 2017, Larson-Green left Microsoft to join Utah-based Qualtrics as Chief Experience Officer.