[2] Julio Grondona's career in football began in 1956, when he and his brother Héctor founded Arsenal Fútbol Club, inspired by the homonymous English side, in Sarandí, Avellaneda, Buenos Aires.

While holding the Arsenal de Sarandi presidency, he also held positions in neighboring club Independiente, where he was elected as chair of the professional football subcommittee in 1962.

In 1979 Grondona was elected to succeed Huracán's David Bracuto as head of the Argentine Football Association, immediately after Argentina's 1978 FIFA World Cup win.

[8] In 2014 his son, Humberto, a FIFA official, admitted illegally selling tickets for games at the World Cup in Brazil.

[9] On 2 June 2015, FIFA blamed[10][11] Julio Grondona for approving, in 2007, corrupt payments at the centre of the United States Department of Justice investigation known as FIFA-gate that led to the 47-count indictment against football officials and sports marketing executives.