Notable creators who worked on Jumbo Comics include Jack Kirby (working under a variety of pseudonyms), Bob Kane, Matt Baker, Mort Meskin, Lou Fine, Bob Powell, Mort Leav, Art Saaf, Dick Briefer, Lily Renée, and Ruth Roche.

[3] Indeed, all the material Eisner & Iger prepared for Jumbo Comics #1 (and the subsequent seven issues) had originally appeared in Wags, which was a tabloid-sized publication.

[5] Bob Powell's first published comic-book art is tentatively identified as the uncredited three-page story "A Letter of Introduction," featuring the famed ventriloquist Edgar Bergen and his dummy, Charlie McCarthy, in Jumbo Comics #2 (Oct. 1938).

Three features in Jumbo Comics #1 representing Jack Kirby's first comic-book work following his debut in Wild Boy Magazine:[7] In addition, Dick Briefer produced a serialized adaptation (in five-page installments) of Victor Hugo's 1831 novel The Hunchback of Notre-Dame which ran in the first 8 issues.

Other recurring features: Sheena, Queen of the Jungle — soon became the company's star character, and her adventures appeared in every issue of Jumbo Comics.