In film scores, he has worked with Hans Zimmer and his company Remote Control Productions on Man of Steel and Batman v Superman: Dawn of Justice, as well as composing the scores for Zack Snyder's Justice League, Divergent, Mad Max: Fury Road, Deadpool, Tomb Raider,[2] Alita: Battle Angel, Terminator: Dark Fate, Sonic the Hedgehog (and its sequels), Scoob!, Godzilla vs. Kong, Army of the Dead, Three Thousand Years of Longing and Rebel Moon Part 1 as well as its second part.

After moving to Leeuwarden, at the age of 17, he decided to take a job at a local music store selling keyboards and other digital gear, and began to have an appreciation for the combination of electronic and organic sounds.

[3] It was shortly after he discovered synthesizers that he joined the Dutch new wave ensemble Weekend at Waikiki as a multi-instrumentalist and producer, touring extensively with the band, including through Poland and parts of the Soviet Union, from 1988 to 1991.

[5] Featuring singles such as "Billy Club", "Def Beat", and "Dealing with the Roster", the album combined pounding breakbeat rhythms with elements of rock and psychedelia.

[5] Much of the album's songs featured lyrics and vocals by Patrick "Rude Boy" Tilon, vocalist for the Dutch rap rock band Urban Dance Squad.

While making inroads as a film composer – contributing to movies like Blade (1998) and The Beach (2000) – Holkenborg was asked to remix Elvis Presley's 1968 single "A Little Less Conversation" (with three different music videos) for a 2002 Nike World Cup commercial, titled "Secret Tournament".

Loosely based around the concept of a fictitious pirate radio station, the album's 3PM side features collaborations with The Cure's Robert Smith, Depeche Mode's Dave Gahan, Peter Tosh, Chuck D from Public Enemy, Gary Numan, Solomon Burke, and Saffron, along with the said Elvis Presley remix.

The album was to be launched simultaneously with a fully functioning internet radio station at www.RadioJXL.com, which was to feature exclusive shows and mixes with top EDM producers and DJs, but the undertaking proved to be too expensive and time-consuming to continue.

His fifth album, Booming Back at You, saw Holkenborg cultivate a stronger club sound punctuated by tracks like "1967 Poem", featuring Steve Aoki.

Holkenborg continues to work in the film and television industry, collaborating with composer Hans Zimmer as a sequencer programmer on Christopher Nolan's The Dark Knight Rises.

Since moving into Zimmer's Remote Control Productions studio, the two have worked together on many other musical projects, including Man of Steel, the reboot of the Superman franchise, and a remix of that year's Academy Awards theme song.

[11] He is a member of the Magnificent Six, a collaborative group of five other musicians, consisting of Hans Zimmer, Pharrell Williams, Johnny Marr (from The Smiths), Michael Einziger (from Incubus), Andrew Kawczynski, and Steve Mazzaro.

"Future in Computer Hell (Part 2)", "Synasthesia", and "Dance USA"—all taken from his album Big Sounds of the Drags—were licensed to the racing video game TD Overdrive: The Brotherhood of Speed (2002).

("Burn My Shadow"), Justin Timberlake ("What Goes Around"), Fatboy Slim ("Weapon of Choice"), Coldplay ("Talk"), Bloc Party ("Sunday"), Michael Bublé ("Sway"), Avril Lavigne ("Girlfriend"), Daft Punk ("The Grid"), Madonna ("4 Minutes"), Fischerspooner ("Emerge"), and Hans Zimmer ("Inception" and "Bombers Over Ibiza").

[30] Holkenborg is an associate professor at the ArtEZ Conservatorium, one of the major art institutes in the Netherlands, where he teaches producing, remixing, and music composition.

One example of this was with his biggest hit, a remix of the song "A Little Less Conversation" which was performed by Elvis Presley, a singer who toward the end of his life was addicted to prescription drugs and whose death in 1977 at the age of 42 was at least partially caused by them.