The band formed in 1995 as a recording project for a Canadian youth dramatic production.

In 1996, the band progressed as they practiced in the rehearsal room in the basement of the University of Toronto radio station CIUT.

The band's fifth full-length album, entitled You, You're a History in Rust, was released on Constellation Records in February 2007.

In June 2009 at Luminato, Toronto's annual festival of arts and creativity, the band provided part of the live soundtrack for the outdoor screening (at Yonge-Dundas Square) of the 1919 silent German horror film Tales Of The Uncanny (Unheimliche Geschichten), alongside Canadian violinist Owen Pallett and electronica music artist Robert Lippok from Berlin, Germany.

Constellation Records released Do Make Say Think's sixth album, titled Other Truths, in October 2009.