This painful experience motivated her to become educated about obstetrics,[1] and she began her practice in 1659,[1] when she was asked to assist a case of obstructed labour related to a misplaced fetal arm.

Her expertise and dexterity caught the attention of Frederick William, Elector of Brandenburg, who appointed her as his court midwife in Berlin in 1683.

She had incorporated embryological and anatomical engravings from Regnier de Graaf and Govard Bidloo, which enhanced its practical utility.

From April to June 1689, she protected her intellectual property stake in the volume through gaining printing privileges from the Electors of Brandenburg and Saxony, as well as the Holy Roman Emperor.

Based on careful notes that she had made during her deliveries, she published an authoritative obstetrical text titled The Court Midwife (German: Die Kgl.

She also is credited (along with François Mauriceau) of finding a method to deal with a hemorrhaging placenta previa by puncturing the amniotic sac.

On 28 March 2023, as part of their Women's History Month campaign, Google celebrated Siegemund with a doodle whose reach included the US, the UK, Iceland, Switzerland, Greece and Germany.