The station's musical lineup includes mainstream and fusion jazz, blues, Americana music, Southern gospel, urban gospel, Latin contemporary, classic rock, oldies, urban contemporary, world music, classic R&B, indie rock and alternative rock.

KALA carries the syndicated weekly Pink Floyd program "Floydian Slip."

[3] During the week, KALA features public service programming (both syndicated and locally produced).

The station also features live radio programs, St. Ambrose University campus news, a local calendar of events, daily weather updates, and student-run music shows.

This includes SAU's Fighting Bees/Queen Bees basketball, football, and baseball, softball, soccer, and more.