The station is owned by KTRS-AM License, L.L.C., a consortium of local investors which includes actor and St. Louis native John Goodman.

Zack Beining has an agricultural show with "Farmer Dave" Schumacher, followed by McGraw Milhaven and Kelly Jackson in morning drive time, Jennifer Blome and Wendy Wiese in late mornings, John Carney and Julie Buck in early afternoons, Heidi Glaus and Josh Gilbert in afternoon drive time, The Big Sports Show with Brendan Weise in the early evening followed by Ray Hartmann at night.

Weekend programming includes shows on money, health, the outdoors, technology, home improvement, movies and pets, with occasional sports events.

KSD carried NBC's schedule of dramas, comedies, news, sports, soap operas, game shows and big band broadcasts during the "Golden Age of Radio."

[6] At the end of World War II, KSD put a television station on the air.

In 1983, the AM station gave up the heritage call sign; the call letters continue on KSD-FM, now owned by iHeartMedia, Inc. As network programming passed from radio to television, KSD switched to a full service, middle of the road format, playing popular adult music, with news, talk and sports shows.

Then as Top 40 radio became more popular, KSD switched to a contemporary hits format in early 1971.

March 17, 1993 saw the restoration of the KSD call sign and a switch back to all-news, this time utilizing the CNN Headline News network feed.

In late 2005, KTRS Morning Show hosts Bill Wilkerson and Wendy Wiese, sports director Jim Holder (at the time the public address announcer at the Edward Jones Dome for the NFL Rams' games), Randy Karraker, McGraw Milhaven, Kevin Horrigan, Scott St. James and Meme Wolff were all fired.

Management, including program director Al Brady Law, announced plans to bring in a new lineup beginning in January 2006.

Steve Cochran, who later worked at WGN in Chicago, hosted a weekday evening talk show on KTRS from 2010 until 2013.

After five years (2006–10), KTRS sold the rights to St. Louis Cardinals baseball games to KMOX starting in 2011.

[9] The Cardinals nonetheless retained their ownership stake in KTRS and still airs the games of its owned-and-operated farm club, the Memphis Redbirds.