The primary transmitter for the station is located about 3 miles west of the community of Seward, Oklahoma (between the cities of Guthrie and Edmond).

On August 20, 2012, KOSU unveiled a new tag line, "Uniquely Oklahoma", and implemented changes in their daily schedule with new news/talk and music programs.

At the core of the changes was a content partnership with The Spy FM, which can be heard on weeknights and sporadically on the weekends on KOSU.

[3] In February 2013, Oklahoma State University received a $150-thousand grant from the Ethics and Excellence in Journalism Foundation in support of a new broadcast facility for KOSU.

In June 2014, KOSU announced that it would be joining the Clinton Global Initiative Project to Preserve American Indian Languages.