KIAA0753

The most distant orthologs of human KIAA0753 were discovered to be the giant owl limpet and a species of acorn worm.

A large number of phosphorylation sites are predicted with high confidence and provide evidence that, in humans, KIAA0753 is located inside the cell rather than exported out.

[12] The individuals conducting this experiment have identified that centrosome duplication is regulated by the following proteins: PLK4, CEP192, CEP152, CEP63, and CPAP.

Their findings conclude that KIAA0753 positively regulates CEP63 centrosome localization and centriole duplication.

A second study has to do with the identification of hepatic microvascular adhesion-related genes of human colon cancer cells.

The article concludes that the identified genes, including KIAA0753, may contribute to understand the metastatic process of colon cancer and possible treatments.

Further analysis of this interaction reveals that it is not due to neighboring or co-occurrence, but has been discovered experimentally.