2LE8, 2WVR8162067177ENSG00000167513ENSMUSG00000006585Q9H211Q8R4E9NM_030928NM_026014NP_112190NP_080290CDT1 (Chromatin licensing and DNA replication factor 1) is a protein that in humans is encoded by the CDT1 gene.

[5][6][7][8] It is a licensing factor that functions to limit DNA from replicating more than once per cell cycle.

The protein encoded by this gene is a key licensing factor in the assembly of pre-replication complexes (pre-RC), which occurs during the G1 phase of the cell cycle.

[10] This regulation is important in preventing relicensing, thus ensuring that DNA is only replicated once per cell cycle.

Examples of orthologs in other species include: DNA replication factor CDT1 has been shown to interact with SKP2.