The bike and team debuted relatively late in the year with Australian rider Anthony West.

[2] On its debut, West shocked many when he scored an impressive second place in a wet British grand prix, fighting for the lead after then-leader Hiroshi Aoyama crashed out with fifteen laps to go.

[5] The team initially scored decent point results, but Aoyama impressed when he won KTM's first 250cc race at only the third round of the season in Turkey, fighting with Alex de Angelis and Héctor Barberá on the flat-out charge to the final chicane on the last lap.

In San Marino however, it was Aoyama who picked up another KTM podium after he finished second behind Jorge Lorenzo.

Mika Kallio scored a third-place finish at the opening round in Qatar and improved upon his efforts at the next round in Spain by scoring the team's first victory of the season, profiting from a last-lap collision between Marco Simoncelli and Álvaro Bautista.

[23][24][25] After a few lacklustre races, Kallio's third victory arrived in Great Britain, beating Simoncelli by 0.353 seconds.

Aoyama scored KTM's final pole position on Saturday[27] and second place podium finish at the Malaysian round,[28] before the team's permanent departure from the 250cc class.