The Honda RS250R was a race motorcycle manufactured by Honda to race in the 250cc class of the Grand Prix motorcycle World Championship.

The RS250R debuted in 1984 as a development prototype, racing in the domestic All Japan Road Race Championship and entering some rounds in the World Championship.

It was put on sale for customer teams for the 1985 season onwards.

The Honda RS250R featured a V-twin 250 cc two-stroke engine with a V-angle of 90 degrees.

This motorcycle, scooter or moped-related article is a stub.