KTWB is a radio station in Sioux Falls, South Dakota airing a country music format.

The station is owned by Duey E. Wright, through licensee Midwest Communications, Inc. Its studios are located on South Phillips Avenue in Sioux Falls, while its transmitter is located near Rowena.

After a 52-year history in Sioux Falls radio, Midcontinent sold all of its stations, including KTWB, to Backyard Broadcasting of Baltimore in 2004.

[1] Backyard sold its seven Sioux Falls stations in 2012 to their present owner, Midwest Communications, in a $13.35 million transaction.

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