It stars Mona Singh, Ashutosh Gowariker, Amey Wagh, Vikas Kumar, Chinmay Mandlekar, Sukant Goel, Arushi Sharma, Radhika Mehrotra, and Poornima Indrajith in lead roles.

[1][2] When a mysterious disease comes down upon the Andaman and Nicobar Islands, a desperate effort for survival collides with a race to discover a remedy laced with human connections and the tale of love, loss, and despair.

[17] Shilajit Mitra of The Hindu wrote "The grim ecological backdrop of Kaala Paani is both leavened and reinforced by the small human moments in the fore, with its middle-class characters fuzzing over wafers and nicknames in the face of looming tragedy.

"[20] Reviewing for Rediff.com, a critic Deepa Gahlot wasn't impressed by the series and stated "Kaala Paani has a lot going for it -- the scenic locations, the cast, and a problem of modern-day apathy towards the environment, that is putting all of humanity on a power keg waiting to explode".

[21] The Free Press Journal opined "Effectively written by Saxena, Golani and Biswapati Sarkar, Kaala Paani stands as a fitting metaphor to a similar predicament that we all were in for a brief period.