Kachi Mayu (Quechua kachi salt, mayu river,[1] "salt river", hispanicized spelling Cachi Mayu) is a Bolivian river east of Poopó Lake in the Oruro Department, Challapata Province, Challapata Municipality.

Its source, the Jach'a Juqhu River, is considered the origin of the Pillku Mayu.

[2] The Jach'a Juqhu River (Aymara jach'a big, great, juqhu muddy place,[1] "great muddy place", hispanicized Jachcha Jokho) originates in the Sebastián Pagador Province (which is identical to the Santiago de Huari Municipality), Condo "C" Canton[3][4] at a height of 4,600 m south west of the mountain Wila Qullu.

Now the river successively receives the names T'ula Pallqa, Aguas Calientes and Kachi Mayu.

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