The original building, which unfortunately exists no more, dates back to before World War I and was built by the Franciscan Capuchin Order.

After the National Ministry of Education decided to open a high school in Kadikoy district, negotiations that lasted many years took place between the ministry and the Capuchins.

After a new education structure was established by the Ministry of Education, the School's name changed from Kadıköy Maarif Koleji to its present name, Kadıköy Anadolu Lisesi (KAL).

Like Galatasaray High School and Istanbul High School, it used to have a 2-year English preparation period with a following independent curriculum, but in 2006 KAL adopted the regular 4-year lycee education following a 1-year prep period.

With over 1500 students, and a 94.1% university entrance ratio, it is, and always has been one of the most important high schools in Turkey.