The Kadohadacho traditionally lived at the borders of Texas, Oklahoma, Arkansas,[5] and Louisiana.
They cultivated crops, such as corn, beans, squash, and pecans, and manufactured bows and pottery for trade.
[6] Traveling parties of Kadohadacho encountered the Hernando De Soto expedition in 1541, but the Spaniards did not enter their territory.
Some remnants of the tribe fled west and joined the Nassoni and the Caddoan-speaking Natchitoches.
[9] By the late 18th century, the remaining Kadohadacho joined their Nachitoches relatives in northwestern Louisiana.