[7] Kainos was founded as a joint venture between Fujitsu and The Queen's University of Belfast business incubation unit (QUBIS Ltd) on 14 April 1986.

[8][9] In January 1987, the company began trading in the QUBIS building on Malone Road, Belfast and Kainos founder, Frank Graham, was appointed managing director.

[10] A spin-off company of Kainos was established in 1994 called Lagan Technologies, which grew to become a software supplier into local government in the UK and the US.

[14] In September 2004, Kainos entered into a partnership agreement with Mediasurface, the UK's largest content management provider.

[19] On 19 November 2014, Kainos announced its plans to expand the Evolve Electronic Medical Records platform into Ireland.