[13][14] Before starting her PhD, Sadtler held a one-year postbaccalaureate research position at the National Institute of Allergy and Infectious Diseases, where she says she "caught the immunology bug.

[15] Sadtler was a postdoctoral fellow with Robert S. Langer and Daniel Anderson at the Massachusetts Institute of Technology, where she focused on how the modulation of immune response influenced tissue development.

"[18] She was also named an inaugural (2018) Convergence Scholar for her work in nanomedicine by the Koch Institute[19] and honored as one of the Forbes 30 Under 30 in 2019 for her doctoral research on immune rejection of medical devices.

[20] Sadtler organized the first population-wide serosurvey for COVID-19 in the United States, considered critical in developing an understanding of asymptomatic transmission rates.

[28] Although the study is still undergoing peer-review, Sadtler explained her hopes for eventual follow-up to assess both antibody duration and reinfection frequency.