[3] Spitzer has worked with film in 35mm, 120 and large format, as well as wet plate collodion process using an 8-by-10 camera.
At the age of 20, she returned to the Yukon, where she is originally from, and documented the cultural practices around hunting, fishing, trapping, tanning moose and caribou hides, and beading.
[4] She is also known to use tintype photography as a means to place her work "in dialogue with the problematic history of Native American imagery by white photographers".
Spitzer's photograph Sister (2016) is the image used as the basis for the sculpture Every One, which is part of the social engagement work called the MMIWQT Bead Project by artist Cannupa Hanska Luger.
[6] The work was made up of over 4,000 clay beads made by people all over North America as to create portrait in a way to "rehumanize data" surrounding missing and murdered Indigenous women, girls, queer and trans people.