[2] She signed with Virgin EMI Records to release her debut studio album Isolation (2018), which peaked at number 34 on the Billboard 200 and saw widespread acclaim.

She then signed with Interscope Records to release her second studio album and first Spanish-language project, Sin Miedo (del Amor y Otros Demonios) (2020).

It spawned the single "Telepatía", which first gained virality on TikTok and marked her first entry on the Billboard Hot 100 at number 25, also receiving double platinum certification by the Recording Industry Association of America (RIAA).

[19][20] The following month, Uchis released "Tyrant", featuring English singer Jorja Smith, to serve as the lead single from her then-upcoming debut studio album.

[22] In October 2017, Uchis was nominated for a Latin Grammy Award for Record of the Year for "El Ratico", her collaboration with Colombian musician Juanes.

[25] "After the Storm", a track featuring Tyler, the Creator and Bootsy Collins, was issued as the third single in January 2018, followed by the announcement of Isolation, in March 2018, which took place during Uchis' appearance on The Tonight Show.

[32] In December 2019, Uchis released "Solita",[33] originally planned to be the lead single of her upcoming second studio album,[34] it was later excluded from the final tracklist.

[39] "Aquí Yo Mando" serves as the lead single from Uchis' second studio album, Sin Miedo (del Amor y Otros Demonios), which is her first project predominantly sung in Spanish.

[48] Following the resurgence of the song, the success garnered Sin Miedo (del Amor y Otros Demonios) to chart on the Billboard 200, peaking at number 52.

[50] On April 21, 2022, Uchis announced on the red carpet of the Latin American Music Awards that she has completed her third and fourth studio albums, with one in Spanish and one in English.

[51] On August 15, 2022, she shared a snippet of a house-influenced song titled "No Hay Ley" on her social media,[52] which was released as a single on September 2, 2022.

[54] On January 23, 2023, Uchis announced her third studio album Red Moon in Venus, which was released on March 3, 2023, with an accompanying tour featuring special guest Raye.

[56] On February 24, 2023, Uchis released the song "Moonlight" as the second single for Red Moon in Venus, featuring production credits from Benny Blanco, Cashmere Cat, and Leon Michels.

[57] Red Moon in Venus was released on March 3, 2023, featuring guest appearances from Omar Apollo, Toliver, and Summer Walker.

[59][60][61][62] On August 11, 2023 "Mañana Será Bonito (Bichota Season)" album of the Colombian singer Karol G was released on which Uchis collaborated on the song "Me tengo que ir".

"[70] She also mentioned that she enjoys jazz, stating during her career beginnings that she draws musical inspiration from Ella Fitzgerald and Billie Holiday.

[76] In January 2024, she announced that she was expecting her first child with Toliver via the music video for her songs "Tu Corazón Es Mío" and "Diosa".