[3] After graduating college, Henderson began training with his current coach Kevin Lightburn at Straightright Boxing[4] in Springdale, Arkansas.

After his amateur career, Henderson made his professional debut on April 30, 2016, scoring a first-round technical knockout (TKO) over Tiriik Johnson at the Fisher Armory in Little Rock, Arkansas.

On June 4, 2022, now with a record of 15 wins, 1 draw, and 1 loss, Henderson faced WBA super-middleweight champion Davild Morrell for the title at the Minneapolis Armory in Minnesota, broadcast on Showtime.

In the anticipated title fight, which broke attendance records at the Minneapolis Armory,[14] Morrell would win via fourth-round TKO stoppage despite some counterpunching attempts from Henderson.

[10] In January of 2025, Henderson went viral on social media after photos of a bloodied boxer/influencer Jake Paul began circulating on several boxing websites.