Kamakahelei (c. 18th century - 1794), was the 22nd aliʻi nui, or High Chiefess regnant, of the island of Kauaʻi.

She was the sovereign of the island of Kauaʻi at the time Captain James Cook landed on its shores.

His family had traditionally ruled in Waimea and the south-western section of the island, although always in subordination to the elder line of Kauaʻian chiefs.

[citation needed] After Kamakahelei's death in 1794, her husband Kāʻeokūlani may have briefly taken regency over his son as he did his nephew Kalanikūpule's inheritance of Mauʻi.

Her son Kaumualiʻi continued to ruled the kingdom of Kauaʻi independently until he consented to becoming a vassal of Kamehameha the Great.