Qamber Ali Khan (Urdu: قمبر علی خان) is a city in the north-west of the Sindh province of Pakistan.

Hot days continue from May till September, followed by Monsoon Rains, sometime bringing floods in the nearby areas.

On July 8, 2003, Qamber experienced a cloudburst of 209 mm (8.2 in) in just 12 hours due to a well marked low pressure which came from Bay of Bengal.

Qamber Ali Khan experienced a powerful hailstorm in April 2006 and again on 14 March 2015 followed by heavy downpour.

The majority of the population in district Qamber Ali Khan speak the native Sindhi language.