Despite his initial disinterest, Aruto changes his mind after witnessing MetsubouJinrai.net's terrorist attacks firsthand; maintaining appearances as CEO while becoming Kamen Rider Zero-One to realize his late father's wish for a peaceful co-existence between humans and Humagears.

All the while, Gai Amatsu, the CEO of tech giant conglomerate and Hiden's corporate rival ZAIA Enterprise, initially watches their battles from afar before moving forward with his agenda to destroy all Humagears and create a society only for humans with his company in the forefront.

He later develops the Kamen Rider Thouser system to achieve his goals and personally enter the fray as well as devices to transform humans into “Raiders”.

As the ideals of Aruto, Gai, and MetsubouJinrai.net collide, a three-way battle takes place to decide the future for both Humagears and humankind.

Producer Takahito Omori had visited several technological institutes and spoke with many professors and experts on the topic of artificial intelligence.

With the show's heavy technology theme, the name "Zero-One" was chosen as a reference to binary code and the trademark was registered by Toei on April 19, 2019.

Two members of the band Monkey Majik revealed that they will be providing the voices for the Hiden Zero-One Driver and the Progrise Keys.

As a result of the ongoing COVID-19 pandemic in Japan, the filming schedule changed and the series' television broadcast was delayed following episode 35.

During the break period, Zero-One released five special episodes that reflect past events as recounted by the main characters.

[16] On October 18, 2020, it was announced that the film will be double billed with Kamen Rider Saber Theatrical Short Story: The Phoenix Swordsman and the Book of Ruin.

The theme song is "GAME CHANGER" performed by Hiroyuki Takami, who reprised his role as Masamune Dan in the first entry.