At the end of the Edo period, Kameyama Castle was home to the Ishikawa clan, daimyō of Ise-Kameyama Domain.

In 1632, while under control of the Miyake clan, the tenshu was demolished in error by Horio Torizane, who had confused ambiguously-worded orders by the shogunate with a command to rebuild the keep of Kameyama Castle in Tanba Province.

A specially-constructed palace was built in the main enclosure for the exclusive use of the Shogun, and the daimyō of the castle was forced to reside in the Ni-no-Maru Second Bailey.

[3] One survivor is the entrance to the Ni-no-maru daimyō residence, which is incorporated into the main hall of the temple of Tensho-ji in the Nishimachi neighborhood of Kameyama.

A Buddhist temple of recent origin, Ōmoto-ji, and the Kameyama City History Museum stand on the grounds.