Kami-shima (神島) is an inhabited island at the mouth of Ise Bay off the east coast of central Honshu, Japan.

The name for Kami-shima has alternatively been written as Kameshima (亀島) or Kajima (歌島).

Archaeologists have found hundreds of ceremonial artifacts on the island, ranging from ancient mirrors to ceramics dating from the Kofun period through the Muromachi period.

The economy of the island is based on commercial fishing in its adjacent waters, and on tourism.

The island is the setting for the 1954 novel by Yukio Mishima The Sound of Waves, and has been used several times as a filming location for movies.