Wyatt made her professional debut on 5 December 2014, scoring a fourth-round technical knockout (TKO) victory against Christina Barry at the Shaw Conference Centre in Edmonton, Alberta, Canada.
In what was the first world championship boxing match to be held in Greece, Wyatt was knocked down three times in the sixth round en route to the first defeat of her career, losing via sixth-round TKO.
[7] Following a UD defeat against Alma Ibarra in August 2021,[8] Wyatt faced reigning champion Jessica McCaskill for the undisputed female welterweight title on 4 December at the MGM Grand Garden Arena in Paradise, Nevada.
[9] Wyatt won a split decision against Kirstie Bavington to claim the vacant WBA female welterweight Intercontinental title in Wolverhampton, England, on 10 March 2023.
[10] In her next fight on 1 July 2023, she challenged for the vacant IBF female welterweight World title at Manchester Arena in England but was stopped in the eighth-round by Natasha Jonas.