Kara-Suu (Kyrgyz: Кара-Суу району, romanized: Kara-Suu rayonu) is a district of Osh Region in south-western Kyrgyzstan.

Its area is 3,616 square kilometres (1,396 sq mi),[2] and its resident population was 448,608 in 2021.

[1] The administrative seat lies at the city Kara-Suu.

[2] In total, Kara-Suu District include 1 city and 137 settlements in 16 rural communities (ayyl aymagy).

The rural communities and settlements in the Kara-Suu District are:[3]