Karachi City Station was first established along the southern edge of McLeod Road (now I. I. Chundrigar Road) as the southern terminus point of the Scinde Railway, which was established in March 1855.

[3][4] The station was completed in May 1864,[5] and was upgraded in the 1880s with construction of a building farther to the west.

[8] The station was upgraded again in 1935,[9] when the current building made of local yellow Gizri sandstone was built.

The station has current and advance reservation offices for Pakistan Railways as well as cargo and parcel facilities.

Due to the lack of space, most passenger trains have since been moved to Karachi Cantonment Station.