Karatau Nature Reserve (Kazakh: Қаратау мемлекеттік табиғи қорығы, Qaratau memlekettık tabiği qoryğy) is a wildlife refuge in the mid-part of the Karatau Mountains, near Kyzylkum, Betpak-Dala and Moiynkum deserts in the South Kazakhstan Region of Kazakhstan, in Central Asia.

Some 700 species of plants constitute its flora, 62 species are endemic.

Its fauna includes, among others, the Kara Tau argali, Indian crested porcupine and beech marten.

There are 118 bird species in the area.

This Kazakhstan location article is a stub.